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	Provedor de dados BJMBR (4) Rev. Bras. Ciênc. Avic. (1) Autor Aoki,M.S. (2) Miyabara,E.H. (2) Moriscot,A.S. (2) Fu,R (1) Guo,Lian-Yi (1) Henrique-Silva,F. (1) Liu,Pei (1) Salvini,T.F. (1) Silveira,H.C.S. (1) Soares,A.G. (1) Soares-Costa,A. (1) Sommer,C.A. (1) Song,J (1) Sun,Y (1) Wang,Gui-Jun (1) Wang,Hong-Xin (1) Wen,J (1) Yang,Y (1) Yao,Yu-Sheng (1) Mais... Palavra-chave Calcineurin (5) Ca2+/calmodulin-dependent protein kinase (1) Calcium (1) Calmodulin-dependent kinase (1) Chicken (1) Cyclosporin A (1) Cyclosporin-A (1) Down's syndrome (1) Down's syndrome candidate region 1 (1) Fast and slow twitch muscles (1) Hypertrophy (1) Immobilization (1) Myocardial hypertrophy (1) Protein interactions (1) Recovery (1) Regeneration (1) Regulation. (1) Skeletal muscle (1) Tumor necrosis factor α (1) Two-hybrid system (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (2) Ano 2015 (1) 2012 (1) 2006 (1) 2005 (1) 2004 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript BJMBR Silveira,H.C.S.; Sommer,C.A.; Soares-Costa,A.; Henrique-Silva,F.. The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. As an approach to clarifying a putative function for this protein, in the present study we used the yeast two-hybrid system to identify DSCR1 partners. The two-hybrid system is a method that allows the identification of protein-protein interactions through reconstitution of the activity of the yeast GAL 4 transcriptional activator. The gene DSCR1 fused to the GAL 4 binding domain (BD) was used to screen a human fetal brain cDNA library cloned in fusion with the GAL 4 activation domain (AD). Three positive clones were found and sequence analysis revealed that all the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Down's syndrome; Down's syndrome candidate region 1; Calcineurin; Two-hybrid system; Ubiquitously expressed transcript; Protein interactions. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600002 Cyclosporin A preferentially attenuates skeletal slow-twitch muscle regeneration BJMBR Miyabara,E.H.; Aoki,M.S.; Moriscot,A.S.. Calcineurin, a Ca2+/calmodulin-dependent phosphatase, is associated with muscle regeneration via NFATc1/GATA2-dependent pathways. However, it is not clear whether calcineurin preferentially affects the regeneration of slow- or fast-twitch muscles. We investigated the effect of a calcineurin inhibitor, cyclosporin A (CsA), on the morphology and fiber diameter of regenerating slow- and fast-twitch muscles. Adult Wistar rats (259.5 ± 9 g) maintained under standard conditions were treated with CsA (20 mg/kg body weight, ip) for 5 days, submitted to cryolesion of soleus and tibialis anterior (TA) muscles on the 6th day, and then treated with CsA for an additional 21 days. The muscles were removed, weighed, frozen, and stored in liquid nitrogen. Cryolesion did... Tipo: Info:eu-repo/semantics/other Palavras-chave: Calcineurin; Cyclosporin A; Regeneration; Fast and slow twitch muscles. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400009 Cyclosporin-A does not affect skeletal muscle mass during disuse and recovery BJMBR Aoki,M.S.; Miyabara,E.H.; Soares,A.G.; Salvini,T.F.; Moriscot,A.S.. Cyclosporin-A (CsA) is an immunosuppressive drug that acts as an inhibitor of calcineurin, a calcium phosphatase that has been suggested to play a role in skeletal muscle hypertrophy. The aim of the present study was to determine the effect of CsA administration (25 mg kg-1 day-1) on skeletal muscle mass and phenotype during disuse and recovery. Male Wistar rats received vehicle (N = 8) or CsA (N = 8) during hind limb immobilization (N = 8) and recovery (N = 8). Muscle weight (dry/wet) and cross-sectional area were evaluated to verify the effect of CsA treatment on muscle mass. Muscle phenotype was assessed by histochemistry of myosin ATPase. CsA administration during immobilization and recovery did not change muscle/body weight ratio in the soleus (SOL)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcineurin; Immobilization; Recovery; Skeletal muscle; Hypertrophy; Cyclosporin-A. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200011 The Expression of Can and Camk is Associated with Lipogenesis in the Muscle of Chicken Rev. Bras. Ciênc. Avic. Yang,Y; Song,J; Fu,R; Sun,Y; Wen,J. ABSTRACTIntramuscular fat (IMF) content in chickens significantly contributes to meat quality. The main objective of this study was to assess the expression of calcineurin (CaN) and Ca2+/calmodulin-dependent protein kinase (CaMK) in lipogenesis in chicken muscle. Chickens were slaughtered and sampled at 4, 8, and 16 weeks of age. IMF content and the expression of CaN subunits and CaMK isoforms were measured in the thigh muscle tissue. The results showed that the IMF contents were greater at 16 weeks compared with those at 4 and 8 weeks (p<0.05). Transcription of fatty acid synthase (FAS) and fatty acid translocase CD36 (FAT/CD36) mRNA significantly increased with age, from four to 16 weeks (p<0.05). The mRNA levels of CaNB and CaMK IV were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ca2+/calmodulin-dependent protein kinase; Calcineurin; Chicken; Regulation.. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2015000300287 The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy BJMBR Wang,Gui-Jun; Wang,Hong-Xin; Yao,Yu-Sheng; Guo,Lian-Yi; Liu,Pei. We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (100 μg/L), and Ca2+ signal transduction was blocked by several antagonists, including BAPTA (4 µM), KN-93 (0.2 µM) and cyclosporin A (CsA, 0.2 µM). Protein content, protein synthesis, cardiomyocyte volumes, [Ca2+]i transients, CaMKIIδB and CaN were evaluated by the Lowry method, [³H]-leucine incorporation, a computerized image analysis system, a Till imaging system, and Western blot analysis, respectively. TNF-α induced a significant increase in protein content in a dose-dependent manner... Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial hypertrophy; Tumor necrosis factor α; Calcium; Calmodulin-dependent kinase; Calcineurin. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100008 Registros recuperados: 5 Primeira ... 1 ... Última

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